• Top NFL player props Week 3 deliver high-value betting opportunities despite 2025’s injury challenges.
• Standout bets include Bijan Robinson’s rushing yards, Rome Odunze’s receiving totals, and Juwan Johnson’s touchdown potential.
• Weak defenses like the Panthers and Giants create exploitable matchups for these props.
• Backed by 2025 stats, these picks are tailored for smart betting on Sunday’s slate.

Breaking Down Week 3’s Betting Opportunities

I’ve been a football junkie since my days betting on college bowl games, and Week 3 of the 2025 NFL season is packed with betting potential. With injuries, especially at quarterback, shaking up game plans, the prop market is buzzing with mismatches. 

The top NFL player props Week 3 slate offers a chance to cash in on players poised to exploit weak defenses. From a running back ready to run wild to a tight end hunting for six, these picks are grounded in stats, trends, and that instinct you get from living for Sundays. Let’s dive into the best bets for September 21.

Bijan Robinson: Over 79.5 Rushing Yards (-114, FanDuel)

Among the top NFL player props Week 3, Atlanta’s dynamic running back stands out. The Carolina Panthers’ run defense is porous, allowing 141 rushing yards per game through Week 2 (seventh-worst, per ESPN). 

Last year, they gave up a league-high 175.7 yards per game, and Robinson dominated them, racking up 265 yards and four touchdowns in two matchups. At -114 on FanDuel (new users get $300 in bonus bets with a winning $5 wager), this prop is a bargain—I’d play it up to 100 yards.

Rome Odunze: Over 44.5 Receiving Yards (-115, Fanatics)

Chicago’s rookie receiver is a gem in the top NFL player props Week 3 lineup. With 10 targets per game and a 128-yard outburst against Detroit in Week 2 (NFL.com), Odunze is Caleb Williams’ go-to guy. Facing a Dallas team favored to lead, per Bet365, Chicago may need to air it out to keep pace, just like last week. Odunze has cleared 44.5 yards in both games this season, making this prop a solid play for a pass-heavy game script.

Isiah Pacheco: Over 35.5 Rushing Yards (-118, BetMGM)

This prop shines among top NFL player props Week 3, especially at BetMGM (offering up to $1,500 in bonus bets if your first bet loses). 

Kansas City’s Pacheco has just 15 carries through two weeks, but the New York Giants’ defense—surrendering a league-worst 177.5 rushing yards per game and 5.9 yards per carry—is a dream matchup. 

Even at his 7.5-carry average, Pacheco can hit this line, but as a road favorite, expect more touches in this prime-time showdown.

George Pickens: Over 53.5 Receiving Yards (-111, DraftKings)

Dallas’ big-play wideout makes the top NFL player props Week 3 list in a game with a high total (DraftKings odds). Chicago’s defense is getting roasted, allowing a league-high 18.78 yards per reception to wideouts in 2025. 

Pickens could clear this line on one deep ball, similar to Jameson Williams’ 64-yard catch last week. At -111 on DraftKings (with $200 in bonus bets and NFL Sunday Ticket discounts for new users), this prop is a must-bet.

Juwan Johnson: Anytime Touchdown (+360, FanDuel)

New Orleans’ tight end is a breakout candidate in Week 3. With 10 targets per game and a 90% route participation rate (Pro Football Focus), Johnson’s tied for the most red-zone targets among tight ends (three). 

Seattle’s defense has been shaky against tight ends, allowing 58 yards to Pat Freiermuth and Jonnu Smith in Week 2 and a touchdown to George Kittle in Week 1. At +360 odds, Johnson’s a high-reward bet to score with Spencer Rattler feeding him in the red zone.

Read also: NFL Week 3 Predictions: Top Bets and Matchups for 2025

Why These Props Are Your Week 3 Ticket

Props are like picking the MVP of your fantasy team—you’ve got to nail the matchups. With injuries reshaping Week 3, these top NFL player props Week 3 picks target players ready to capitalize on vulnerable defenses. 

From Robinson’s ground game to Johnson’s red-zone role, these bets blend 2025 stats with years of watching football’s ups and downs. So, lock in your wagers, grab your game-day snacks, and let’s make Week 3 a winner. Here’s to big plays and bigger payouts!

Aliha

Hi, I’m Aliha! I’ve been a huge NFL fan for as long as I can remember, and I love sharing my thoughts, updates, and insights about the game. Whether it’s big plays, team news, or behind-the-scenes stories, writing about the NFL gives me a chance to connect with fellow fans who share the same passion for football.