• Our NFL Week 4 predictions highlight a potential Ravens upset over the Chiefs, flipping their historical rivalry.
• Seattle’s stout defense makes them a strong pick against the Cardinals on Thursday night.
• Jordan Love and the Packers could dominate Dallas, with Micah Parsons’ return adding drama.
• The Chargers are set to challenge Giants rookie QB Jaxson Dart in his NFL debut.
• Get ready for close contests and surprises with these data-driven NFL Week 4 predictions.

As a football fan who’s spent years cheering through thrilling Sundays, I know the NFL can be unpredictable. Week 3 humbled me—my picks, like Green Bay’s loss to Cleveland, stung. But the beauty of football is the chance to bounce back. Here are my NFL Week 4 predictions, blending stats, trends, and a touch of instinct. All odds are from DraftKings and BetMGM as of September 25, 2025, unless noted.

Seattle Seahawks vs. Arizona Cardinals

When: Thursday, 8:15 p.m. ET (Prime Video)
Pick: Seahawks -1.5
Projected Score: Seahawks 24, Cardinals 20

Seattle’s defense, allowing just 4.7 yards per play (top 10), makes them a solid bet. Their red zone defense ranks third, and they’re second in points allowed. Arizona’s banged-up secondary leaves openings for Sam Darnold, while Kyler Murray’s 0-7 record against Seattle looms large. This feels like a game where Seattle’s balance wins out.

Cincinnati Bengals vs. Denver Broncos

When: Monday, 8:15 p.m. ET (ABC | Fubo)
Pick: Broncos -7.5
Projected Score: Broncos 31, Bengals 17

Cincinnati’s offense is struggling, ranking last in yards (220.7) and rushing (49.0). Denver’s second-best red zone defense (27.3% touchdown rate) spells trouble for Jake Browning. The Broncos, hungry after a 1-2 start, should exploit Cincinnati’s defense, which allows 30.3 points per game. Denver pulls away at home.

Green Bay Packers vs. Dallas Cowboys

When: Sunday, 8:20 p.m. ET (NBC | Fubo)
Pick: Packers -7
Projected Score: Packers 28, Cowboys 19

Micah Parsons’ return to Dallas after his trade to Green Bay is the storyline, but Jordan Love could steal the show. Dallas’ defense has struggled, and with injuries to their offensive line, Love (3-0 on Sunday Night Football) should shine. Coach Matt LaFleur’s 12-3 ATS record in these spots adds confidence.

Los Angeles Chargers vs. New York Giants

When: Sunday, 1 p.m. ET (CBS | Paramount+)
Pick: Chargers -6
Projected Score: Chargers disinfection26, Giants 16

Giants rookie Jaxson Dart has hype, but the Chargers’ top-ranked red zone defense (25% touchdown rate) and third-best opponent passer rating (67.9) make this a tough debut. Justin Herbert’s MVP-level play tilts this game heavily in LA’s favor.

Baltimore Ravens vs. Kansas City Chiefs

When: Sunday, 4:25 p.m. ET (CBS | Paramount+)
Pick: Ravens -2.5
Projected Score: Ravens 26, Chiefs 23

Despite Kansas City’s 5-1 edge over Lamar Jackson, I’m picking Baltimore. The Chiefs’ offense is at its lowest since 2018 (20 points, 315.7 yards per game). Baltimore’s 1-2 start came against strong teams, and their talent shines through. Jackson gets his moment.

Other Week 4 Picks

• Vikings vs. Steelers (Dublin): Vikings 20, Steelers 16 (Pick: Vikings -2.5)
• Panthers vs. Patriots: Patriots 23, Panthers 20 (Pick: Panthers +5.5)
• Browns vs. Lions: Lions 28, Browns 15 (Pick: Lions -10)
• Saints vs. Bills: Bills 29, Saints 16 (Pick: Saints +16.5)
• Eagles vs. Buccaneers: Eagles 25, Buccaneers 22 (Pick: Eagles -3.5)
• Titans vs. Texans: Texans 22, Titans 18 (Pick: Titans +7)
• Commanders vs. Falcons: Commanders 27, Falcons 19 (Pick: Commanders -1.5)
• Colts vs. Rams: Rams 26, Colts 23 (Pick: Colts +3.5)
• Jaguars vs. 49ers: 49ers 25, Jaguars 21 (Pick: 49ers -3.5)
• Bears vs. Raiders: Bears 24, Raiders 20 (Pick: Bears +1.5)
• Jets vs. Dolphins (Monday): Jets 25, Dolphins 22 (Pick: Jets +2.5)

Jaxson Dart’s Rookie of the Year Chances

Dart’s preseason buzz has him in the OROY conversation, but this Chargers matchup is a tough test. His dual-threat skills keep him relevant—check BetMGM for updated odds.

Final Thoughts

These NFL Week 4 predictions are my shot at redemption after a rough week. From Lamar Jackson’s potential breakthrough to Jordan Love’s primetime magic, this weekend’s games are packed with storylines. Grab your game-day gear and enjoy the action—here’s to a winning week!

Read also: Top NFL Player Props Week 3

Aliha

Hi, I’m Aliha! I’ve been a huge NFL fan for as long as I can remember, and I love sharing my thoughts, updates, and insights about the game. Whether it’s big plays, team news, or behind-the-scenes stories, writing about the NFL gives me a chance to connect with fellow fans who share the same passion for football.