• Get the latest betting odds, predictions, and TV schedules for NFL Week 3 games in 2025, including a marquee matchup between the Ravens and Lions.
• Discover which teams are favored, from the Bills’ big spread against the Dolphins to tight contests like Bears vs. Cowboys.
• Learn how to watch every game, with streaming options like FOX Sports and Amazon Prime Video.
• Gain insights into key matchups to make informed betting decisions or enhance your viewing experience.
• Stay updated with game times, locations, and expert NFL Week 3 predictions for all 16 games.

Get Ready for NFL Week 3 Action

As a lifelong football fan, I can tell you Week 3 of the NFL season is when things start to heat up. Teams are finding their rhythm, rivalries are sparking, and every game feels like a stepping stone to the playoffs. 

In 2025, Week 3 brings a slate of thrilling matchups, headlined by the Baltimore Ravens taking on the Detroit Lions. Whether you’re a bettor looking for an edge or a fan planning your game-day watch party, this guide breaks down the NFL Week 3 predictions, odds, and viewing details for every game. Let’s dive into the action!

Top NFL Week 3 Matchups and Betting Insights

Here’s your comprehensive look at the Week 3 schedule, complete with betting odds from FanDuel, expert NFL Week 3 predictions, and where to catch each game. I’ve been following the NFL for years, and trust me, these details can make or break your game-day strategy.

Thursday Night Football

Buffalo Bills vs. Miami Dolphins

• Spread: Bills (-11.5)
• Moneyline: Bills -806, Dolphins +558
• Over/Under: 49.5 points
• Prediction: Bills 32, Dolphins 15
• When and Where: Thursday, September 18, 2025, 8:15 p.m. ET, Orchard Park, NY
• How to Watch: Amazon Prime Video
• Why It Matters: The Bills are coming in hot, favored heavily against a Dolphins team struggling to find its footing. Expect Buffalo’s high-powered offense to dominate.

Sunday Early Games (1 p.m. ET)

Cleveland Browns vs. Green Bay Packers

• Spread: Packers (-7.5)
• Moneyline: Packers -437, Browns +336
• Over/Under: 41.5 points
• Prediction: Packers 30, Browns 13
• When and Where: Sunday, September 21, 2025, Cleveland, OH
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: Green Bay’s defense should overwhelm a Browns offense still searching for consistency.

Tampa Bay Buccaneers vs. New York Jets

• Spread: Buccaneers (-6.5)
• Moneyline: Buccaneers -300, Jets +242
• Over/Under: 44.5 points
• Prediction: Buccaneers 32, Jets 15
• When and Where: Sunday, September 21, 2025, Tampa, FL
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: Tampa Bay’s veteran leadership gives them the edge over a Jets team dealing with quarterback uncertainty.

New England Patriots vs. Pittsburgh Steelers

• Spread: Steelers (-1.5)
• Moneyline: Steelers -126, Patriots +106
• Over/Under: 44.5 points
• Prediction: Steelers 25, Patriots 17
• When and Where: Sunday, September 21, 2025, Foxborough, MA
• How to Watch: CBS
• Why It Matters: This classic AFC clash is a toss-up, but Pittsburgh’s home-field grit could tip the scales.

Carolina Panthers vs. Atlanta Falcons

• Spread: Falcons (-5.5)
• Moneyline: Falcons -251, Panthers +204
• Over/Under: 43.5 points
• Prediction: Falcons 29, Panthers 21
• When and Where: Sunday, September 21, 2025, Charlotte, NC
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: Atlanta’s offense is clicking, making them a solid bet against a rebuilding Panthers squad.

Washington Commanders vs. Las Vegas Raiders

• Spread: Commanders (-3.5)
• Moneyline: Commanders -188, Raiders +157
• Over/Under: 44.5 points
• Prediction: Commanders 32, Raiders 16
• When and Where: Sunday, September 21, 2025, Landover, MD
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: Washington’s dynamic playmakers should exploit the Raiders’ defensive weaknesses.

Jacksonville Jaguars vs. Houston Texans

• Spread: Jaguars (-1.5)
• Moneyline: Jaguars -121, Texans +101
• Over/Under: 44.5 points
• Prediction: Texans 25, Jaguars 19
• When and Where: Sunday, September 21, 2025, Jacksonville, FL
• How to Watch: CBS
• Why It Matters: This AFC South showdown could go either way, but Houston’s home-field advantage might make the difference.

Tennessee Titans vs. Indianapolis Colts

• Spread: Colts (-3.5)
• Moneyline: Colts -203, Titans +167
• Over/Under: 43.5 points
• Prediction: Colts 25, Titans 21
• When and Where: Sunday, September 21, 2025, Nashville, TN
• How to Watch: CBS
• Why It Matters: The Colts’ balanced attack gives them a slight edge in this divisional rivalry.

Philadelphia Eagles vs. Los Angeles Rams

• Spread: Eagles (-3.5)
• Moneyline: Eagles -185, Rams +155
• Over/Under: 44.5 points
• Prediction: Eagles 28, Rams 16
• When and Where: Sunday, September 21, 2025, Philadelphia, PA
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: Philly’s physical style should overpower a Rams team still finding its identity.

Minnesota Vikings vs. Cincinnati Bengals

• Spread: Vikings (-3)
• Moneyline: Vikings -160, Bengals +134
• Over/Under: 41.5 points
• Prediction: Vikings 30, Bengals 19
• When and Where: Sunday, September 21, 2025, Minneapolis, MN
• How to Watch: CBS
• Why It Matters: Minnesota’s defense could capitalize on Cincinnati’s injury-riddled offense.

Sunday Afternoon Games

Seattle Seahawks vs. New Orleans Saints

• Spread: Seahawks (-7.5)
• Moneyline: Seahawks -383, Saints +302
• Over/Under: 41.5 points
• Prediction: Seahawks 28, Saints 15
• When and Where: Sunday, September 21, 2025, 4:05 p.m. ET, Seattle, WA
• How to Watch: CBS
• Why It Matters: Seattle’s home dominance makes them a safe bet against a struggling Saints team.

Los Angeles Chargers vs. Denver Broncos

• Spread: Chargers (-2.5)
• Moneyline: Chargers -154, Broncos +130
• Over/Under: 46 points
• Prediction: Chargers 22, Broncos 21
• When and Where: Sunday, September 21, 2025, 4:05 p.m. ET, Inglewood, CA
• How to Watch: CBS
• Why It Matters: This tight AFC West battle could come down to the final drive.

Chicago Bears vs. Dallas Cowboys

• Spread: Bears (-1)
• Moneyline: Bears -109, Cowboys -110
• Over/Under: 51 points
• Prediction: Bears 24, Cowboys 20
• When and Where: Sunday, September 21, 2025, 4:25 p.m. ET, Chicago, IL
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: A high-scoring affair is expected, with the Bears’ momentum giving them a slight edge.

San Francisco 49ers vs. Arizona Cardinals

• Spread: 49ers (-1.5)
• Moneyline: 49ers -127, Cardinals +107
• Over/Under: 44 points
• Prediction: Cardinals 25, 49ers 22
• When and Where: Sunday, September 21, 2025, 4:25 p.m. ET, Santa Clara, CA
• How to Watch: FOX, FOXSports.com, FOX Sports App, FOX One (7-day free trial)
• Why It Matters: Arizona’s scrappy play could upset a 49ers team dealing with injuries.

Sunday Night Football

New York Giants vs. Kansas City Chiefs

• Spread: Chiefs (-6.5)
• Moneyline: Chiefs -298, Giants +241
• Over/Under: 45.5 points
• Prediction: Chiefs 28, Giants 12
• When and Where: Sunday, September 21, 2025, 8:20 p.m. ET, East Rutherford, NJ
• How to Watch: NBC
• Why It Matters: Kansas City’s firepower should overwhelm the Giants in primetime.

Monday Night Football

Baltimore Ravens vs. Detroit Lions

• Spread: Ravens (-4.5)
• Moneyline: Ravens -236, Lions +195
• Over/Under: 52.5 points
• Prediction: Ravens 27, Lions 26
• When and Where: Monday, September 22, 2025, 8:15 p.m. ET, Baltimore, MD
• How to Watch: ABC/ESPN
• Why It Matters: This high-scoring clash could be the game of the week, with Baltimore’s experience edging out Detroit’s tenacity.

Why Week 3 Matters for Fans and Bettors

Week 3 is a pivotal moment in the NFL season. As someone who’s spent countless Sundays glued to the TV, I know these early games set the tone for playoff races. For bettors, the NFL Week 3 predictions—like the Bills’ massive -11.5 spread or the tight Bears-Cowboys line—offer opportunities to capitalize on trends. For fans, it’s about catching every play, whether you’re streaming on FOX Sports or watching on CBS. The variety of close games and blowouts makes this week a must-watch.

Final Thoughts: Don’t Miss the NFL Week 3 Excitement

Growing up, NFL Sundays were sacred in my house, and Week 3 of the 2025 season feels like one for the books. From the Ravens-Lions showdown to underdog stories like the Cardinals’ upset potential, this week is packed with drama. 

Whether you’re placing bets, cheering for your team, or just soaking in the action, these matchups remind us why football is America’s favorite sport. Grab your snacks, fire up your streaming app, and get ready for a weekend of unforgettable moments.

Read also: Packers Jayden Daniels Prediction

Aliha

Hi, I’m Aliha! I’ve been a huge NFL fan for as long as I can remember, and I love sharing my thoughts, updates, and insights about the game. Whether it’s big plays, team news, or behind-the-scenes stories, writing about the NFL gives me a chance to connect with fellow fans who share the same passion for football.